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SIRT1PROTEIN

There are 4 papers on SIRT1PROTEIN in aging research: 1 trial in people, 2 in animals, 1 in cells.

Gene

4 papers study it5 findings

See all 4 papers on SIRT1PROTEIN

At a glance

The findings reach people, from one lab or study. 4 independent labs in 4 countries.

None of its findings points the other way.

Cells, mice and humans: a single group. Worms or flies: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 4 independent labs in 4 countries
  • Funders: Alfred Benzon Foundation and others
  • Human trial1
  • Animals2
  • Cells1

Interventions

3

ANTI-miR-200C

upin mice1

1 study

  1. ANTI-miR-200C increases SIRT1PROTEIN in mice after transient MCAO.

    “In males, anti-miR-200c increased Sirt1 protein expression”

    Animalsafter transient MCAObrainmales

    Sexual Dimorphism in Brain Sirtuin-1 and m6A Methylated Sirtuin-1 mRNA, and in Protection with Post-Injury Anti-miR-200c treatment, after Experimental Stroke in Aged Mice

    Aging and disease

More on ANTI-miR-200C

Unsaturated fatty acid enriched high-fat diet

no changein humans1

1 study

  1. Unsaturated fatty acid enriched high-fat diet showed no clear effect on SIRT1PROTEIN in humans.

    “while remaining unchanged after Unsat”

    Human trialunsaturated fatty acid enrichedskeletal muscle+75% energy (E%); 78 E% fat3 dmales

    Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Unsaturated fatty acid enriched high-fat diet

Saturated fatty acid enriched high-fat diet

upin humans1+40% increase

1 study

  1. Saturated fatty acid enriched high-fat diet increases SIRT1PROTEIN in humans (~40% increase).

    “After Sat, SIRT1 protein content and activity in skeletal muscle increased ( P < 0.05; ∼40%)”

    Human trialsaturated fatty acid enrichedskeletal muscle+75% energy (E%); 79 E% fat3 dmales

    Fatty acid type-specific regulation of SIRT1 does not affect insulin sensitivity in human skeletal muscle

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

More on Saturated fatty acid enriched high-fat diet

Upstream

2

NUR77

upin mouse cells1

1 study

  1. NUR77 increases SIRT1PROTEIN in mouse cells (shown by overexpression; protection from proteasomal degradation).

    “Overexpression of Nr4a1 protected the Sirt1 protein from proteasomal degradation through negative transcriptional regulation of the E3 ligase MDM2”

    Cellsshown by overexpression; protection from proteasomal degradation

    Oxidative stress impairs the Nur77-Sirt1 axis resulting in a decline in organism homeostasis during aging

    Aging cell

More on NUR77

CK2

downin human cells1

1 study

  1. CK2 decreases SIRT1PROTEIN in human cells (CK2 downregulation).

    “CK2 downregulation destabilized SIRT1 protein via an ubiquitin-proteasome pathway in human cells”

    CellsCK2 downregulation

    Defect of SIRT1-FoxO3a axis is associated with the production of reactive oxygen species during protein kinase CK2 downregulation-mediated cellular senescence and nematode aging

    BMB reports

More on CK2

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