Cdkn2a
GeneMus musculus7 papers1 findingMGI 104738NCBI Gene 12578Taxon 10090
- Animals7
Upstream
1Trp53
downin mouse cells1
1 study
Trp53
downin mouse cells1
Trp53 inhibits Cdkn2a in mouse cells.
Cellsin senescent macrophagesmacrophage
A distinct p21-driven macrophage senotype accumulates during aging and liver disease · bioRxiv · 28 Sep 2026 · Preprint
Latest
7Exercise protects mouse hearts from chemotherapy toxicity by suppressing cellular senescence
Physical activity preserved cardiac function and sustained FNDC5 and irisin signaling in mice exposed to doxorubicin.
Research Square · Jeyabal P et al.
A distinct p21-driven macrophage senotype accumulates during aging and liver disease
Researchers identified a p53-p21-Cyclin D2 axis that governs senescent macrophages in mice and human liver cirrhosis and can be cleared with senolytics.
bioRxiv · Torres G et al.
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · Chen X et al.
Hallmarks of Aging Associate with High Intensity Interval Training Benefits and Frailty in Female C57Bl/6J Mice
Erigeron breviscapus extends worm lifespan and reduces senescence markers in mice
The herbal extract activates AMPK-SIRT1 signaling, enhancing antioxidant defenses and modulating apoptosis to alleviate tissue aging across both model organisms.
Biogerontology · Pu Y et al.
CD47 blockade reduces doxorubicin-induced cardiac aging in male mice
Inhibiting CD47 lessens heart dysfunction and blunts cellular senescence caused by the chemotherapy drug doxorubicin.
Physiological reports · Yan A et al.