BMF

1. Oxidative stress-preconditioned exosomes decrease BMF in cells.

   “BMF (Bcl2 modifying factor) was identified as a functionally relevant downstream target suppressed by O-Exos”

   Cellsin NP cells

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

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1. BMF increases intervertebral disc degeneration.

   “Bmf deficiency promoted mitophagy and alleviated IDD.”

   Animalsshown by Bmf deficiency

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

More on Intervertebral disc degeneration

1. BMF decreases fertile life span in mice.

   “the fertile life span of Bmf(-/-) females was significantly extended compared to WT females”

   Animalsshown by knockoutfemales

   Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

   Biology of reproduction·10 Apr 2014

1. BMF decreases offspring production in mice.

   “Bmf(-/-) females produced litters more frequently and consequently more offspring than WT females over a 6-mo period”

   Animalsshown by knockout6-mo periodfemales

   Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

   Biology of reproduction·10 Apr 2014

1. BMF decreases primordial follicles in mice.

   “Bmf(-/-) mice had significantly more primordial follicles than wild-type (WT) control animals at Postnatal Days 100, 200, 300, and 400”

   Animalsshown by knockoutovaryfemales

   Loss of the proapoptotic BH3-only protein BCL-2 modifying factor prolongs the fertile life span in female mice

   Biology of reproduction·10 Apr 2014

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