Oxidative stress-preconditioned exosomes

1. Oxidative stress-preconditioned exosomes decrease BMF in cells.

   “BMF (Bcl2 modifying factor) was identified as a functionally relevant downstream target suppressed by O-Exos”

   Cellsin NP cells

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

More on BMF

1. Oxidative stress-preconditioned exosomes increase mitophagy in cells.

   “The superior effects of O-Exos were associated with restoration of mitophagy and improved mitochondrial homeostasis in TNF/TNF-α-treated NP cells.”

   Cellsin TNF/TNF-alpha-treated NP cells

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

More on Mitophagy

1. Oxidative stress-preconditioned exosomes decrease cellular senescence in cells.

   “O-Exos more effectively delayed nucleus pulposus (NP) cell senescence and attenuated IDD in vitro and in vivo.”

   Cellsin TNF/TNF-alpha-treated NP cells

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

More on Cellular senescence

1. Oxidative stress-preconditioned exosomes decrease intervertebral disc degeneration.

   “O-Exos more effectively delayed nucleus pulposus (NP) cell senescence and attenuated IDD in vitro and in vivo.”

   Animalsin TNF/TNF-alpha-treated NP cells and in vivo IDD

   Oxidative stress-preconditioned exosomes target BMF to restore mitophagy for alleviating intervertebral disc degeneration

   Autophagy·22 Jun 2026

More on Intervertebral disc degeneration