Bone marrow mesenchymal stem cell-derived exosomes
Intervention1 paper4 findings
- Animals1
Outcomes
4Tissue repair
upin rats1Very low certainty
1 study
Tissue repair
upin rats1Very low certainty
Bone marrow mesenchymal stem cell-derived exosomes improve tissue repair in rats.
Animalshindlimb ischemia; compared with exosomes from older donorsexosomes from young rat donorshindlimb
Young-donor cell packages improved limb repair in rats · Stem cell research & therapy · 6 Oct 2026
BACH1 protein expression
downin human cells1Very low certainty
1 study
BACH1 protein expression
downin human cells1Very low certainty
Bone marrow mesenchymal stem cell-derived exosomes decrease BACH1 protein expression in human cells.
Cellscompared with exosomes from older donorsexosomes from young rat donorshuman umbilical vein endothelial cell
Young-donor cell packages improved limb repair in rats · Stem cell research & therapy · 6 Oct 2026
Endothelial colony formation, migration, and tube formation
upin human cells1Very low certainty
1 study
Endothelial colony formation, migration, and tube formation
upin human cells1Very low certainty
Bone marrow mesenchymal stem cell-derived exosomes increase endothelial colony formation, migration, and tube formation in human cells.
Cellsoxygen-glucose deprivation/reoxygenation injury; compared with injury aloneexosomes from older rat donorshuman umbilical vein endothelial cell
Young-donor cell packages improved limb repair in rats · Stem cell research & therapy · 6 Oct 2026
Post-ischemic perfusion recovery
upin rats1Very low certainty
1 study
Post-ischemic perfusion recovery
upin rats1Very low certainty
Bone marrow mesenchymal stem cell-derived exosomes improve post-ischemic perfusion recovery in rats.
Animalsunilateral hindlimb ischemiaexosomes from young and older rat donorshindlimb
Young-donor cell packages improved limb repair in rats · Stem cell research & therapy · 6 Oct 2026
Latest
1Young-donor cell packages improved limb repair in rats
In a rat experiment, cell-released packages from young donors had stronger tissue-repair effects than those from older donors after blood supply was…In a rat experiment, cell-released packages from young donors had stronger tissue-repair effects than those from older donors after blood supply was restricted.