2 papers
Washington University School of Medicine
1 trialPhase 240 people
National Institute on AgingUS$1.6mNational Heart, Lung, and Blood InstituteUS$1.4mNational Institute on Drug AbuseUS$723.4k
Mitigating HIV-Associated Premature Aging Through Cannabinoid-Mediated Anti-Inflammatory Mechanisms
National Institute on Drug AbuseLsu Health Sciences CenterUS$723.4k2026–2031
Targeting Novel Senescence-Associated Pathways to Combat Premature Aging in People with HIV
National Institute on AgingNorthwestern UniversityUS$794.7k2026–2031
Premature aging disorders, metabolites, and atherosclerosis
National Heart, Lung, and Blood InstituteUniversity of Tx Md Anderson Can CtrUS$691.4k2022–2027
Towards Developing Biomarkers for Premature Aging in Schizophrenia
National Institute of Mental HealthBrigham and Women's HospitalUS$249k2023–2028
Role of IL-32 as a predictor and mediator of Premature Aging Phenotypes(PAP) in HIV infection.
National Institute on AgingSante Quebec Centre Hospitalier De L'universite De MontrealUS$829.3k2016–2027
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.
Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere…Boosting telomerase in blood-forming cells extended lifespan in immune-deficient zebrafish and partly restored gut health, operating without major changes in telomere length.
Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.
Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.Lipid nanoparticle delivery of base-editing mRNA restored DNA repair and heterochromatin structure in human neuromuscular models of premature aging.
All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04) versus neither.All-cause mortality was higher with premature ovarian failure (adjusted hazard ratio 2.50), depression (1.64), and both conditions combined (5.04) versus neither.