Among 31,604 matched pairs, people taking the drugs had a dementia hazard ratio of 0.454 compared with statin users, indicating lower relative risk.Among 31,604 matched pairs, people taking the drugs had a dementia hazard ratio of 0.454 compared with statin users, indicating lower relative risk.
Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.Experiments in neurons made from healthy donors aged 11 to 91 found impaired removal of damaged mitochondria, the cells’ energy-producing structures.
Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.Removing the protein from brain support cells accelerated aging-related changes and impaired nervous system function in mouse experiments.
The system classified patients at the subjective cognitive decline stage with more than 95% accuracy, offering a possible route to earlier Alzheimer's diagnosis.The system classified patients at the subjective cognitive decline stage with more than 95% accuracy, offering a possible route to earlier Alzheimer's diagnosis.
Experiments in aged mice and mouse models of amyotrophic lateral sclerosis found less nervous system inflammation and degeneration after researchers deleted or inhibited…Experiments in aged mice and mouse models of amyotrophic lateral sclerosis found less nervous system inflammation and degeneration after researchers deleted or inhibited the protein.
Mouse experiments found that raising the molecule caused cognitive decline, while drugs blocking certain enzymes counteracted the induced inflammation and cognitive…Mouse experiments found that raising the molecule caused cognitive decline, while drugs blocking certain enzymes counteracted the induced inflammation and cognitive changes.
An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.An observational study followed 1,396 generally healthy adults aged 36–108 for an average of 5.0 years, separating cognitive performance from subsequent decline.
A Mendelian randomization analysis of 28 genetic studies linked airborne pollution and lung damage to inflammation and a higher risk of Alzheimer's disease.A Mendelian randomization analysis of 28 genetic studies linked airborne pollution and lung damage to inflammation and a higher risk of Alzheimer's disease.
Mice lacking Frem3 in excitatory brain cells showed widespread brain volume loss between young adulthood and middle age alongside lower cognitive performance.Mice lacking Frem3 in excitatory brain cells showed widespread brain volume loss between young adulthood and middle age alongside lower cognitive performance.
Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.
Among patients under 60, 15-year stroke risk fell from 11% in 1995–2010 to 4% in 2010–2025; dementia risk declined modestly.Among patients under 60, 15-year stroke risk fell from 11% in 1995–2010 to 4% in 2010–2025; dementia risk declined modestly.
