bioRxiv
Brain changes follow a sequence in Christianson syndrome rats
Gene-activity profiling across the lifespan traced early nerve-cell changes, later immune activation and declining capacity to insulate nerve fibers in a rat model.Gene-activity profiling across the lifespan traced early nerve-cell changes, later immune activation and declining capacity to insulate nerve fibers in a rat model.
Preprint: rat studyMechanisms
Who was studiedRats modeling Christianson syndrome, across the lifespan
What changedEarly nerve-cell impairments preceded brain support-cell activation and declining capacity to insulate nerve fibers
The catchGene-activity profiles are proxies for the sequence of functional changes in brain cells
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