2 papers
Veterans AffairsNational Institute on AgingUS$2.5mNational Heart, Lung, and Blood InstituteUS$580.5k
Molecular Mechanisms of Fiber Type-Specific Skeletal Muscle Dysfunction with Aging
National Institute on AgingUniversity of Wisconsin-madisonUS$698.7k2026–2031
Mechanogenetics: An Integrated Approach to Aging in Muscle Dysfunction
National Institute on AgingUniversity of California, San DiegoUS$1.8m2013–2029
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse
Veterans AffairsVA Salt Lake City Health Care System2019–2023
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse
National Heart, Lung, and Blood InstituteUniversity of UtahUS$580.5k2019–2026
In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.In 45 patients with heart failure with preserved ejection fraction, diet and exercise partially reversed altered gene activity and DNA packaging in muscle.
Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.Analysing datasets from 23 muscle donors and 30 early-progression brain donors, researchers identified matching inflammatory gene pathways across tissues.
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.