Irritable bowel syndrome

1. Irritable bowel syndrome decreases NCAM1 in humans.

   “Intestinal NCAM1 expression was lower in IBS”

   Humansin IBSintestine

   Irritable Bowel Syndrome and Incident Hypertension: Epidemiologic and Genetic Insights · Biomedicines · 13 Sep 2026

NCAM1 →

1. Irritable bowel syndrome is associated with hypertension in humans (OR, 1.18; 95% CI, 0.78-1.77).

   “the primary inverse-variance weighted estimate was positive but imprecise (OR, 1.18; 95% CI, 0.78-1.77)”

   Humansinverse-variance weighted Mendelian randomization

   Irritable Bowel Syndrome and Incident Hypertension: Epidemiologic and Genetic Insights · Biomedicines · 13 Sep 2026

2. Irritable bowel syndrome raises the risk of hypertension in humans (HR, 1.26; 95% CI, 1.22-1.30).

   “IBS was associated with incident hypertension (HR, 1.26; 95% CI, 1.22-1.30).”

   Humans14.09 years

   Irritable Bowel Syndrome and Incident Hypertension: Epidemiologic and Genetic Insights · Biomedicines · 13 Sep 2026

Hypertension →