There are 5 papers on incident Alzheimer's disease in aging research: 3 observational studies in people, 1 review. The newest story, Oct 28, 2026: “Some diabetes drugs linked to fewer Alzheimer’s diagnoses”.
5 papers study it72 more mention it10 findings
See all 77 papers on incident Alzheimer's disease
“The UKB-DRP model can achieve high discriminative accuracy in dementia (AUC 0.848 ± 0.007) and even better in AD (AUC 0.862 ± 0.015).”
Hyperlipidemia
upin humans1
Hyperlipidemia predicts incident Alzheimer's disease in humans (Down syndrome).
“Strongest predictors of increased probability of AD were age, dual Medicaid/Medicare enrollment; incident epilepsy or incident ulcer three years before index date; any hypothyroidism, schizophrenia, or hyperlipidemia.”
HumansDown syndrome
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Schizophrenia
upin humans1
Schizophrenia predicts incident Alzheimer's disease in humans (Down syndrome).
“Strongest predictors of increased probability of AD were age, dual Medicaid/Medicare enrollment; incident epilepsy or incident ulcer three years before index date; any hypothyroidism, schizophrenia, or hyperlipidemia.”
HumansDown syndrome
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Hypothyroidism
upin humans1
Hypothyroidism predicts incident Alzheimer's disease in humans (Down syndrome).
“Strongest predictors of increased probability of AD were age, dual Medicaid/Medicare enrollment; incident epilepsy or incident ulcer three years before index date; any hypothyroidism, schizophrenia, or hyperlipidemia.”
HumansDown syndrome
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Ulcer
upin humans1
Ulcer predicts incident Alzheimer's disease in humans (Down syndrome; incident ulcer three years before index date).
“Strongest predictors of increased probability of AD were age, dual Medicaid/Medicare enrollment; incident epilepsy or incident ulcer three years before index date;”
HumansDown syndrome; incident ulcer three years before index date
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Epilepsy
upin humans1
Epilepsy predicts incident Alzheimer's disease in humans (Down syndrome; incident epilepsy three years before index date).
“Strongest predictors of increased probability of AD were age, dual Medicaid/Medicare enrollment; incident epilepsy or incident ulcer three years before index date;”
HumansDown syndrome; incident epilepsy three years before index date
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Gradient boosted trees model
upin humans1
gradient boosted trees model predicts incident Alzheimer's disease in humans (Adults with Down syndrome enrolled in Medicaid and/or Medicare) (AUC 0.86).
“The machine learning model had an area under the curve of 0.86 and high positive predictive value.”
HumansAdults with Down syndrome enrolled in Medicaid and/or Medicare
Novel predictors of Alzheimer's disease in Down syndrome identified using machine learning
Journal of Alzheimer's disease : JAD
Polygenic risk score for plasma total tau
upin humans1HR 1.046
Polygenic risk score for plasma total tau is associated with incident Alzheimer's disease in humans (UK Biobank participants without prevalent dementia) (HR 1.046, 95% CI 1.007–1.086).
“Higher PRStau was also linked to increased AD risk (HR 1.046, 95% CI 1.007-1.086).”
HumansUK Biobank participants without prevalent dementia12.9 ± 2.4 years52% femalesn = 142,637
Neurology
Lower macular retinal nerve fiber layer thickness
upin humans1+11% higher incidence
Lower macular retinal nerve fiber layer thickness is associated with incident Alzheimer's disease in humans After adjustment (11% higher incidence).
“lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively.”
HumansAfter adjustmentmacular retinal nerve fiber layerMedian follow-up 11.3 years47% womensn = 69,955
Alzheimer's & dementia : the journal of the Alzheimer's Association
UKB dementia risk prediction model
upin humans1
UKB dementia risk prediction model predicts incident Alzheimer's disease in humans (Internally validated in a general population of European ancestry and White ethnicity) (AUC 0.862 ± 0.015).
“The UKB-DRP model can achieve high discriminative accuracy in dementia (AUC 0.848 ± 0.007) and even better in AD (AUC 0.862 ± 0.015).”
HumansInternally validated in a general population of European ancestry and White ethnicityMedian 11.9 yearsn = 425,159
EClinicalMedicine
Each 1 gram per cubic meter increase in wildfire smoke particles was associated with 1.029 times the rate of Alzheimer’s disease and related dementias.Each 1 gram per cubic meter increase in wildfire smoke particles was associated with 1.029 times the rate of Alzheimer’s disease and related dementias.
An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of follow-up.An exposome-based model reached an AUC of 0.718 for incident dementia, outperforming demographics and APOE status alone at 0.678 over 15.3 years of follow-up.
Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors.Older adults taking GLP-1 agonists showed higher risks of Alzheimer's disease (RR 1.33) and all-cause mortality (RR 1.11) than those on SGLT2 inhibitors.
Compared with other diabetes medicines, the drug group had a hazard ratio of 0.46 for first recorded Alzheimer’s diagnoses.Compared with other diabetes medicines, the drug group had a hazard ratio of 0.46 for first recorded Alzheimer’s diagnoses.