Lower macular retinal nerve fiber layer thickness

Biomarker

2 findings

“lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively.”
Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studiesAlzheimer's & dementia : the journal of the Alzheimer's Association2023doi:10.1002/alz.13167

Associations

2

Incident Alzheimer's disease

upin humans1+11% higher incidence

1 study
  1. Lower macular retinal nerve fiber layer thickness is associated with incident Alzheimer's disease in humans After adjustment (11% higher incidence).

    “lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively.”

    HumansAfter adjustmentmacular retinal nerve fiber layerMedian follow-up 11.3 years47% womensn = 69,955

    Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies

    Alzheimer's & dementia : the journal of the Alzheimer's Association

More on Incident Alzheimer's disease

Incident all-cause dementia

upin humans1+10% higher incidence

1 study
  1. Lower macular retinal nerve fiber layer thickness is associated with incident all-cause dementia in humans After adjustment (10% higher incidence).

    “lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively.”

    HumansAfter adjustmentmacular retinal nerve fiber layerMedian follow-up 11.3 years47% womensn = 69,955

    Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies

    Alzheimer's & dementia : the journal of the Alzheimer's Association

More on Incident all-cause dementia