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Polygenic risk score for plasma total tau

There is 1 paper on polygenic risk score for plasma total tau in aging research: 1 observational study in people.

Biomarker

1 paper studies it2 findings

See all 1 papers on polygenic risk score for plasma total tau

“Higher PRStau was also linked to increased AD risk (HR 1.046, 95% CI 1.007-1.086).”
Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive ImpairmentNeurology2025doi:10.1212/wnl.0000000000213904
  • Humans1

Associations

2

Incident Alzheimer's disease

upin humans1HR 1.046

1 study

  1. Polygenic risk score for plasma total tau is associated with incident Alzheimer's disease in humans (UK Biobank participants without prevalent dementia) (HR 1.046, 95% CI 1.007–1.086).

    “Higher PRStau was also linked to increased AD risk (HR 1.046, 95% CI 1.007-1.086).”

    HumansUK Biobank participants without prevalent dementia12.9 ± 2.4 years52% femalesn = 142,637

    Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment

    Neurology

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Incident Alzheimer disease or amnestic mild cognitive impairment

upin humans1HR 1.29

1 study

  1. Polygenic risk score for plasma total tau is associated with incident Alzheimer disease or amnestic mild cognitive impairment in humans (Cognitively healthy HELIAD participants at baseline) (HR 1.290, 95% CI 1.006–1.654 per 1 SD increase).

    “A 1 SD increase in PRStau was linked to a 29% higher AD/aMCI risk (hazard ratio [HR] 1.290, 95% CI 1.006-1.654).”

    HumansCognitively healthy HELIAD participants at baseline1 SD increase in PRStau2.92 ± 0.80 years58.4% femalesn = 618

    Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment

    Neurology

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