Dementia risk score

1. Diet decreases dementia risk score in humans.

   “In both DiRECT and DIADEM‐I a significant difference in the change in dementia risk score from baseline to 1‐year between the trial arms was observed”

   Human trialin patients with obesity and T2D1 year

   A proteomic tool suggests reductions in dementia risk following intentional weight loss in type 2 diabetes

   AAIC 2025 abstract·23 Dec 2025

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1. Maintain your brain decreases dementia risk score in humans (p = 0.007).

   “dementia risk ( p = 0.007) all improved”

   Human trial3 years

   Maintain Your Brain: recent findings, future challenges

   AAIC 2025 abstract·23 Dec 2025

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1. Lifestyle recommendations decrease dementia risk score in humans (Z=‐3.98, p < .001).

   “At Y1, women showed lower overall total and supplemented risk scores (Z=‐3.98, p < .001; Z=‐2.855, p = .004).”

   Human trial1 yearfemalesn = 96

   Impact of one year of lifestyle change on Alzheimer's risks and the role of dementia risk and menopause stage on longitudinal memory scores

   AAIC 2025 abstract·23 Dec 2025

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1. Intentional weight loss decreases dementia risk score in humans.

   “greater weight loss associating with a greater reduction in dementia risk”

   Human trialin intervention arm of DiRECT trial1 year

   A proteomic tool suggests reductions in dementia risk following intentional weight loss in type 2 diabetes

   AAIC 2025 abstract·23 Dec 2025

1. Dementia risk score predicts dementia in silico (balanced accuracy 74.59%).

   “For predicting future MCI progression, the balance accuracy was 71.17 % for MRI‐only model, 71.79% for the PET‐only model, and 74.59% for the fused model”

   In silicopredicting future MCI progression to dementia

   Multi‐modal Neuroimaging Based Dementia Risk Score for Early Detection of Future Risk of Dementia Onset for Alzheimer's Disease

   AAIC 2025 abstract·9 Jan 2026

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1. Dementia risk score is associated with verbal learning in humans (r = ‐0.27, p = .07).

   “Greater BL risk scores were marginally related to poorer Y1 verbal learning and memory ( r = ‐0.27, p = .07; r=‐0.27, p = .082).”

   Human trial1 yearfemales

   Impact of one year of lifestyle change on Alzheimer's risks and the role of dementia risk and menopause stage on longitudinal memory scores

   AAIC 2025 abstract·23 Dec 2025

1. Dementia risk score predicts predictive accuracy in humans.

   “Preliminary analyses demonstrate high concordance between traditional dementia risk scores and biomarker profiles in African populations, validating their predictive accuracy following necessary contextual modifications.”

   Reviewfollowing contextual modifications

   Advancing Dementia Risk Prediction and Prevention in Africa Through Precision Health Approaches

   AAIC 2025 abstract·23 Dec 2025

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