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Incident Alzheimer disease or amnestic mild cognitive impairment

There is 1 paper on incident Alzheimer disease or amnestic mild cognitive impairment in aging research: 1 observational study in people.

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“A 1 SD increase in PRStau was linked to a 29% higher AD/aMCI risk (hazard ratio [HR] 1.290, 95% CI 1.006-1.654).”
Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive ImpairmentNeurology2025doi:10.1212/wnl.0000000000213904
  • Humans1

Associations

1

Polygenic risk score for plasma total tau

upin humans1HR 1.29

1 study

  1. Polygenic risk score for plasma total tau is associated with incident Alzheimer disease or amnestic mild cognitive impairment in humans (Cognitively healthy HELIAD participants at baseline) (HR 1.290, 95% CI 1.006–1.654 per 1 SD increase).

    “A 1 SD increase in PRStau was linked to a 29% higher AD/aMCI risk (hazard ratio [HR] 1.290, 95% CI 1.006-1.654).”

    HumansCognitively healthy HELIAD participants at baseline1 SD increase in PRStau2.92 ± 0.80 years58.4% femalesn = 618

    Longitudinal Association of a Polygenic Risk Score for Plasma T-Tau With Incident Alzheimer Dementia and Mild Cognitive Impairment

    Neurology

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