Hepatic inflammation

1 paper

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15 in 12 months

CellsOct 16

Potential Physiological Convergence Between GLP-1 Receptor Signaling and Hepatocyte TAZ in Metabolic Liver Disease: From Metabolic Homeostasis to Fibrotic Remodeling

ReviewExtracellular matrix remodelling

Hepatology CommunicationsOct 16

Hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease (MASLD)

ReviewCellular senescence

Nature MetabolismOct 2

Dasatinib and quercetin reduce liver fibrosis in a phase-2 MASH trial

The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.The senolytic combination improved liver fibrosis without disease worsening in nearly half of treated participants while lowering cellular senescence markers.

Randomized trial in 31 peopleDasatinib + quercetin

Research SquareSep 3

RGS10 controls the metabolic and neuroinflammatory benefits of NLRP3 suppression in diet-induced obesity in male mice

Preprint: experiments in miceInflammation

Aging CellJul 4

A Non-Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Experiments in miceOxidative phosphorylation

Aging CellJun 23

Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice

Experiments in miceMetabolic dysfunction-associated steatotic liver disease

The EMBO JournalJun 23

OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity

Experiments in miceMechanisms

Physiological ReportsJun 17

Partial body mass regain attenuates lipid utilization and alters the hepatic lipidome linked to HDL dysfunction during metabolic syndrome in male rats

Experiments in ratsMetabolic syndrome

Experimental GerontologyMay 23

Aging exacerbates hepatic dysfunction induced by human apoCIII overexpression in transgenic mice

Experiments in 32 miceMechanisms

Frontiers in BioscienceFeb 28

MCC950 Suppresses Hepatic Inflammaging by Inhibiting NLRP3 Inflammasome Activation in Spontaneously Aged Mice

Experiments in miceNLRP3 inflammasome