Dry eye

2 papers1 finding

Associations

1

Meibum hydrocarbon chain unsaturation

downin humans1−13% lower

1 study

Dry eye is associated with meibum hydrocarbon chain unsaturation in humans (~13% lower).
“A cohort with dry eye had a ∼13% lower level of HCunsat”
Humansdry eye cohort vs without dry eye
Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy
Investigative ophthalmology & visual science2 Mar 2026

More on Meibum hydrocarbon chain unsaturation

Trial sponsors

Research Insight
Company1 trialPhase 450 people
Innovative Medical
Company1 trialPhase 4
Allergan
Company1 trialPhase 2/3286 people
Santen
Company1 trialPhase 2143 people
BioTheraVision
Company1 trialPhase 2123 people
Novartis Pharmaceuticals Corporation
Company1 trialPhase 272 people
Ocular Therapeutix
Company1 trialPhase 243 people
Varol TUNALI
Company1 trial20 people

Funding

3 grants since 2022

National Eye InstituteUS$2.5m

Latest

11 in 12 months

Nutrients27 Aug

Obesity and Eye Diseases

ReviewEye

Investigative Ophthalmology & Visual Science30 Mar

Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy

Cross-sectional study in peopleEye

Experimental Eye Research28 Mar

Age-related decline of platelet-derived growth factor receptor alpha in mesenchyme surrounding meibomian gland leads to meibomian gland dysfunction

Experiments in miceMechanisms

eLife25 Mar

NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

Preprint: experiments in miceInterventions

eLife25 Mar

NAD boosting mediated by CD38 inhibition drives reversal of a pathological vicious cycle of intracrine activity and inflammation in eyelid meibomian gland dysfunction

Preprint: experiments in miceInterventions

Cellular & Molecular Biology Letters21 Mar

Intermittent fasting inhibits ferroptosis by modulating CD36 and its palmitoylation to alleviate diabetic dry eye

Experiments in miceIntermittent fasting

Free Radical Biology & Medicine12 Mar

Semaglutide alleviates age-related dry eye disease by restoring lacrimal gland structure and function

Experiments in miceSemaglutide

Frontiers in Bioscience28 Feb

Mimicking Nature, Modulating Vision: Peptidomimetic Neurotrophin Agonists and Emerging Regenerative Strategies in Ocular Disease

ReviewEye

Biochemistry Biokhimiia27 Dec

Suppressing Mitochondrial ROS Production is Beneficial in Multiple Preclinical Models of Human Disease

ReviewInterventions

Aging and Disease26 Nov

Integrative Mechanisms and Emerging Therapies for Lacrimal Gland Aging

ReviewMechanisms