Meibum hydrocarbon chain unsaturation
1 paper3 findings
- Humans1
Upstream
1Age
downin humans1
1 study
Age
downin humans1
Age decreases meibum hydrocarbon chain unsaturation in humans (20% to 40% lower).
“HCunsat levels, normalized to lipid esters, were found to be 20% to 40% lower in individuals aged >50 years compared with those <50 years (P < 0.05)”
Humans
Investigative ophthalmology & visual science2 Mar 2026
Associations
2Sjögren's syndrome
downin humans1−35% lower
1 study
Sjögren's syndrome
downin humans1−35% lower
Sjögren's syndrome is associated with meibum hydrocarbon chain unsaturation in humans (~35% lower).
“cohorts susceptible to dry eye such as those with Sjögren's syndrome, Parkinson's, and graft-versus-host disease had a ∼35% lower HCunsat levels compared with a cohort without dry eye (P < 0.05).”
HumansSjögren's syndrome, Parkinson's, and graft-versus-host disease cohorts vs without dry eye
Investigative ophthalmology & visual science2 Mar 2026
Dry eye
downin humans1−13% lower
1 study
Dry eye
downin humans1−13% lower
Dry eye is associated with meibum hydrocarbon chain unsaturation in humans (~13% lower).
“A cohort with dry eye had a ∼13% lower level of HCunsat”
Humansdry eye cohort vs without dry eye
Investigative ophthalmology & visual science2 Mar 2026
Latest
1 in 12 monthsInvestigative Ophthalmology & Visual Science
Meibum Lipid Saturation Related to Dry Eye, Age, and Sex Using Nuclear Magnetic Resonance Spectroscopy
Cross-sectional study in peopleEye