1 paper1 finding
Senescence-associated beta-galactosidase
upin humans1
Disc degeneration increases senescence-associated beta-galactosidase in humans (P < 0.0001).
“Analysis by ANOVA of the % senescent cells grouped by Thompson grade showed significant increases in senescence with increasing disc degeneration (P < 0.0001).”
Humansintervertebral disc anulus
Spine1 Feb 2007
Company1 trialPhase 2121 people
1 trialPhase 460 people
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In 265,805 people, longer telomeres were linked to lower rates of new spine diagnoses; the hazard ratio, comparing rates over time, was 0.953.In 265,805 people, longer telomeres were linked to lower rates of new spine diagnoses; the hazard ratio, comparing rates over time, was 0.953.
Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.Experiments that altered gene activity in human spinal disc cells found that restoring the protein also reduced senescence, a state in which cells stop dividing.