PhenoAge-Accel

1. PhenoAge-Accel mediates premature mortality in humans (6.0%–29.7% of associations mediated).

   “Furthermore, PhenoAge-Accel mediated 6.0%-29.7% of the associations between reproductive factors and premature mortality.”

   HumansMediation of associations between reproductive factors and premature mortalityfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

1. Healthy lifestyle is associated with PhenoAge-Accel in humans.

   “Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects;”

   HumansAssociation in women with reproductive risk factorsfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

More on Healthy lifestyle

1. Early age at first live birth is associated with PhenoAge-Accel in humans (β 0.66, 95% CI 0.56–0.75).

   “early age at first live birth (<20 years vs 25-29 years, β: 0.66, 95% CI: 0.56, 0.75)”

   HumansFirst live birth before 20 years versus at 25–29 yearsfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

More on Early age at first live birth

1. Short reproductive lifespan is associated with PhenoAge-Accel in humans (β 0.81, 95% CI 0.70–0.92).

   “short reproductive lifespan (<30 years vs 35-39 years, β: 0.81, 95% CI: 0.70, 0.92)”

   HumansReproductive lifespan below 30 years versus 35–39 yearsfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

More on Short reproductive lifespan

1. Early menopause is associated with PhenoAge-Accel in humans (β 0.62, 95% CI 0.51–0.72).

   “early menopause (<45 years vs 50-51 years, β: 0.62, 95% CI: 0.51, 0.72)”

   HumansMenopause before 45 years versus at 50–51 yearsfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

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1. Early menarche is associated with PhenoAge-Accel in humans (β 0.37, 95% CI 0.30–0.44).

   “Early menarche (<12 years vs 13 years, β: 0.37, 95% CI: 0.30, 0.44)”

   HumansMenarche before 12 years versus at 13 yearsfemalesn = 223,729

   Reproductive factors and biological aging: the association with all-cause and cause-specific premature mortality

   Human reproduction (Oxford, England)·13 Nov 2024

More on Early menarche