Perceived stress

2 papers1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Burroughs Wellcome Fund and others

Humans2

Associations

Telomere length

downin humans1

1 study

Perceived stress is associated with telomere length in humans (equivalent of at least one decade of additional aging).
“Women with the highest levels of perceived stress have telomeres shorter on average by the equivalent of at least one decade of additional aging compared to low stress women.”
Humanshighest levels of perceived stress vs low stressperipheral blood mononuclear cellsfemales
Accelerated telomere shortening in response to life stress
Proceedings of the National Academy of Sciences of the United States of America1 Dec 2004