Age-associated pathologies

Disease

1 paper1 finding

Animals1

Interventions

Caloric restriction

downin rhesus monkeys1

1 study

Caloric restriction decreases age-associated pathologies in rhesus monkeys.
“CR delayed the onset of age-associated pathologies.”
Animalsadult-onset20-year
Caloric restriction delays disease onset and mortality in rhesus monkeys
Science (New York, N.Y.)10 Jul 2009

Latest

9 in 12 months

Philosophical Transactions of the Royal Society of London, Series B1 Oct

Proteostasis and ageing dissidence

ReviewProteostasis

Paper

Biochimica et Biophysica Acta General Subjects1 Oct

Chelating intracellular calcium reduces fibroblast senescence and eases lung fibrosis

Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.Treating cells and an in vivo fibrosis model with a calcium chelator delayed senescence markers, reduced collagen buildup, and dampened inflammatory secretions.

Experiments in animalsCellular senescence

Paper

Bulletin of Experimental Biology and Medicine29 Sep

NLRP3 inflammasome activity shifts toward regulating cell fate in aged macrophages

Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.Inhibiting the NLRP3 inflammasome with MCC950 reduced apoptosis but increased senescence in aged bone marrow-derived macrophages.

Experiments in cellsNLRP3 inflammasome

Paper

Antioxidants26 Sep