Nov 6–9, 2026Chicago625 abstracts
A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.A retrospective comparison of 269 people with one heart failure form, 275 with another and 186 controls found different protein-based aging patterns.
An observational analysis of 1,206,874 heart recordings from 374,223 patients linked AI-estimated aging categories to distinct patterns in the heart’s electrical signals.An observational analysis of 1,206,874 heart recordings from 374,223 patients linked AI-estimated aging categories to distinct patterns in the heart’s electrical signals.
In transplant experiments, microbes from young donors partly reversed heart dysfunction in old mice aged 18–24 months.In transplant experiments, microbes from young donors partly reversed heart dysfunction in old mice aged 18–24 months. The researchers studied both mice with an intact Akap1 gene and mice missing one copy.
Adults with low fitness had 3.69 times the odds of an unusually old biological age estimate compared with those with normal fitness.Adults with low fitness had 3.69 times the odds of an unusually old biological age estimate compared with those with normal fitness. Adults aged 18 and older who underwent clinical exercise testing were analyzed in a retrospective…
For death or heart failure admission, the hazard ratio—a relative event-rate measure—was 1.24 per standard-deviation rise in the whole-body age gap.For death or heart failure admission, the hazard ratio—a relative event-rate measure—was 1.24 per standard-deviation rise in the whole-body age gap.
Against clinical criteria, iPhone camera recordings classified healthy vascular aging with 70% overall accuracy in an independent group of 64 adults.Against clinical criteria, iPhone camera recordings classified healthy vascular aging with 70% overall accuracy in an independent group of 64 adults.
Laboratory experiments traced how stem-cell-derived blood vessel cells used nutrients to support DNA building blocks and persistent responses to DNA damage in progeria.Laboratory experiments traced how stem-cell-derived blood vessel cells used nutrients to support DNA building blocks and persistent responses to DNA damage in progeria.
At 10 years, users without diabetes had lower dementia risk than multivitamin users (relative risk 0.17) and phentermine users (0.64).At 10 years, users without diabetes had lower dementia risk than multivitamin users (relative risk 0.17) and phentermine users (0.64). Adults aged 55 or older without diabetes and with a body mass index—a weight-for-height…
Each five-year higher gap between age estimated from heart electrical recordings and actual age was associated with a 53% higher relative risk of death.Each five-year higher gap between age estimated from heart electrical recordings and actual age was associated with a 53% higher relative risk of death.
Over one year, cardiac events occurred in 20.5% of patients whose scan-based heart age exceeded their actual age by at least two years, versus 5.5% otherwise.Over one year, cardiac events occurred in 20.5% of patients whose scan-based heart age exceeded their actual age by at least two years, versus 5.5% otherwise.
Mice lacking the regulator developed high lung blood pressure by 8 months; right-heart pumping pressure exceeded 40 millimeters of mercury, compared with control mice.Mice lacking the regulator developed high lung blood pressure by 8 months; right-heart pumping pressure exceeded 40 millimeters of mercury, compared with control mice.
Removing two activin receptor types from certain immune cells lowered a heart-filling pressure index to 31.93, versus 42.99 in heart-failure mice.Removing two activin receptor types from certain immune cells lowered a heart-filling pressure index to 31.93, versus 42.99 in heart-failure mice.
Compared with another diabetes drug class, the medicines were associated with 1.54 percentage points lower mortality over four years in adults with serious mental…Compared with another diabetes drug class, the medicines were associated with 1.54 percentage points lower mortality over four years in adults with serious mental illness.
Drug users had a lower relative risk of heart or blood vessel events or death than non-users, with an adjusted hazard ratio of 0.42.Drug users had a lower relative risk of heart or blood vessel events or death than non-users, with an adjusted hazard ratio of 0.42. Adults with overweight or obesity—233,018 people with a mean age of 52.4—were compared in a…
An observational analysis of 152,617 women aged 40–65 linked earlier menopausal stages to greater benefits from one class of diabetes and weight-loss drugs.An observational analysis of 152,617 women aged 40–65 linked earlier menopausal stages to greater benefits from one class of diabetes and weight-loss drugs.
High-intensity statin use was linked to lower dementia risk than no statin use, with a relative risk measure called a hazard ratio of 0.54.High-intensity statin use was linked to lower dementia risk than no statin use, with a relative risk measure called a hazard ratio of 0.54.
Combined rates of plaque-related artery disease, vein clots or death before 80 were 10.05 per 1,000 person-years in both hormone therapy users and non-users.Combined rates of plaque-related artery disease, vein clots or death before 80 were 10.05 per 1,000 person-years in both hormone therapy users and non-users.
Over 10 years, the hazard ratio—a comparison of disease rates over time—was 1.61 for participants with the condition versus those without it.Over 10 years, the hazard ratio—a comparison of disease rates over time—was 1.61 for participants with the condition versus those without it.
At 60 months, survival was 83.5% among users of glucagon-like peptide-1 receptor agonists, versus 57.4% among matched nonusers.At 60 months, survival was 83.5% among users of glucagon-like peptide-1 receptor agonists, versus 57.4% among matched nonusers. Adults with confirmed heart failure with preserved ejection fraction were compared in a retrospective…
Stroke rates were 3.4% with one add-on drug class versus 4.0% with blood-pressure drugs alone; mean follow-up across comparisons ranged from 3.6–4.2 years.Stroke rates were 3.4% with one add-on drug class versus 4.0% with blood-pressure drugs alone; mean follow-up across comparisons ranged from 3.6–4.2 years.
At one year, users had a lower relative rate of major heart and blood vessel events than nonusers, with a hazard ratio of 0.40.At one year, users had a lower relative rate of major heart and blood vessel events than nonusers, with a hazard ratio of 0.40. Adults older than 50 with more than three documented cardiovascular risk factors but no established…
Drug users had a lower relative risk of sudden cardiac death than nonusers over five years, with a hazard ratio of 0.45.Drug users had a lower relative risk of sudden cardiac death than nonusers over five years, with a hazard ratio of 0.45. Adults aged 18–45 with morbid obesity, defined as a body mass index of at least 40, were compared in a…
DNA-based estimates suggested former smokers’ overall death risk stayed elevated until 20–25 years after quitting.DNA-based estimates suggested former smokers’ overall death risk stayed elevated until 20–25 years after quitting. Blood samples from 10,127 US male physicians, averaging 67.2 years old, were analyzed in a prospective…
Blood-cell Y chromosome loss was linked to worse heart outcomes in 1,712 men with a heart-muscle disease (hazard ratio 2.19).Blood-cell Y chromosome loss was linked to worse heart outcomes in 1,712 men with a heart-muscle disease (hazard ratio 2.19). The 1,712 men had hypertrophic cardiomyopathy, a disease that thickens heart muscle, and took part in an…
Users of one drug class had a 23–29% lower relative risk than metformin users over 12 months in an observational analysis.Users of one drug class had a 23–29% lower relative risk than metformin users over 12 months in an observational analysis. Adults with type 2 diabetes were included in a retrospective observational analysis of 871,884 matched…
The drugs were associated with lower mortality than metformin alone, with a hazard ratio of 0.55, but no significant reduction in limb complications.The drugs were associated with lower mortality than metformin alone, with a hazard ratio of 0.55, but no significant reduction in limb complications.
Among male mice, 69% given gene therapy were alive at 270 days, while controls had a median survival of 197 days.Among male mice, 69% given gene therapy were alive at 270 days, while controls had a median survival of 197 days. C57BL/6 mice carrying two copies of the Lmna H222P gene variant received one gene-therapy injection at one month of…
Compared with nonusers, drug users had a one-year relative hazard of 0.63 for abnormal lower-chamber heart rhythms or sudden cardiac death.Compared with nonusers, drug users had a one-year relative hazard of 0.63 for abnormal lower-chamber heart rhythms or sudden cardiac death.
At one year, glucagon-like peptide-1 receptor agonists were linked to lower risk than sodium-glucose cotransporter-2 inhibitors, with a hazard ratio of 0.682.At one year, glucagon-like peptide-1 receptor agonists were linked to lower risk than sodium-glucose cotransporter-2 inhibitors, with a hazard ratio of 0.682.
In 5,398 patients, estimates were off by an average of 4.87 milliliters of oxygen per kilogram per minute compared with exercise-test measurements.In 5,398 patients, estimates were off by an average of 4.87 milliliters of oxygen per kilogram per minute compared with exercise-test measurements.
Among adults with low 10-year risk but high 30-year risk or high “bad” cholesterol, 47.71% progressed to higher risk categories within five years.Among adults with low 10-year risk but high 30-year risk or high “bad” cholesterol, 47.71% progressed to higher risk categories within five years.
An immune-cell activator improved right-heart function in rats with established high blood pressure in the lung arteries; the study ended 10 days after treatment.An immune-cell activator improved right-heart function in rats with established high blood pressure in the lung arteries; the study ended 10 days after treatment.
An observational study of 20,461 participants followed for a median 8.6 years linked more daily steps to lower high blood pressure, obesity and type 2 diabetes risk.An observational study of 20,461 participants followed for a median 8.6 years linked more daily steps to lower high blood pressure, obesity and type 2 diabetes risk.
More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.More than 1,200 blood proteins were linked to future heart failure about 18 years before diagnosis, rising to about 3,600 closer to diagnosis.
Heart failure events or death occurred in 6.1% of oral semaglutide users versus 8.9% of sitagliptin users over one year.Heart failure events or death occurred in 6.1% of oral semaglutide users versus 8.9% of sitagliptin users over one year. Adults with type 2 diabetes and heart failure linked to excess body fat—whose hearts pumped out a normal…
Each extra hour of deep sleep was linked to 13.5% lower relative risk; each extra hour of rapid eye movement sleep to 11.3% lower risk.Each extra hour of deep sleep was linked to 13.5% lower relative risk; each extra hour of rapid eye movement sleep to 11.3% lower risk. The 43,704 Fitbit-linked participants in this observational cohort had no previous diagnosis…
High scores were associated with 65% lower relative risk of cardiovascular events or cardiovascular death than low scores over 18.7 years.High scores were associated with 65% lower relative risk of cardiovascular events or cardiovascular death than low scores over 18.7 years. The 18,453 postmenopausal women in this observational analysis averaged 63.6 years of age…
Heart attacks occurred in 3.88% of oral semaglutide users versus 4.31% of injectable users over three years in matched medical-record cohorts.Heart attacks occurred in 3.88% of oral semaglutide users versus 4.31% of injectable users over three years in matched medical-record cohorts.
In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis.In-hospital mortality was 37.1% in the high-frailty group versus 16.3% in the low-frailty group in a national database analysis. People admitted urgently with heart failure-related cardiogenic shock—when the heart cannot pump…
Adding 250 chemical markers improved risk models beyond standard clinical measures in an observational study of 54,933 Kaiser Permanente biobank participants.Adding 250 chemical markers improved risk models beyond standard clinical measures in an observational study of 54,933 Kaiser Permanente biobank participants.
A cohort study followed 261,291 women and 205,873 men for a median 15.4 years, finding that risk-factor links differed by age when disease began.A cohort study followed 261,291 women and 205,873 men for a median 15.4 years, finding that risk-factor links differed by age when disease began.
Heart failure flare-ups had a hazard ratio—a relative risk measure—of 0.69 over one year with added drugs versus standard care alone.Heart failure flare-ups had a hazard ratio—a relative risk measure—of 0.69 over one year with added drugs versus standard care alone. Adults with obesity and heart failure with reduced ejection fraction—a condition in which the…
During follow-up from 2018 through 2023, dementia occurred in 6.8% of adults with both disorder types versus 2.3% with neither.During follow-up from 2018 through 2023, dementia occurred in 6.8% of adults with both disorder types versus 2.3% with neither. Adults aged 40–90 in the All of Us Research Program were studied in a retrospective cohort analysis of…
The equation scored 0.822 on a measure of how well it distinguished cardiovascular deaths from other outcomes, outperforming machine-learning models in 5,690 adults.The equation scored 0.822 on a measure of how well it distinguished cardiovascular deaths from other outcomes, outperforming machine-learning models in 5,690 adults.
Underweight was linked to a higher risk of cardiovascular death, with a hazard ratio—a measure of relative risk—of 1.56 compared with normal weight.Underweight was linked to a higher risk of cardiovascular death, with a hazard ratio—a measure of relative risk—of 1.56 compared with normal weight.
Each doubling of the blood protein osteopontin was linked to hazard ratios of 1.16 for atrial fibrillation and 1.30 for dementia.Each doubling of the blood protein osteopontin was linked to hazard ratios of 1.16 for atrial fibrillation and 1.30 for dementia. Participants in the Atherosclerosis Risk in Communities study included 3,964 people assessed for…
Seven-year rates of atrial fibrillation, an irregular heartbeat, were 6.4% in people flagged by an artificial intelligence heart-tracing model, versus 2.1% in those not…Seven-year rates of atrial fibrillation, an irregular heartbeat, were 6.4% in people flagged by an artificial intelligence heart-tracing model, versus 2.1% in those not flagged.
The model scored 0.810 on a measure of distinguishing people who developed atrial fibrillation within 10 years from those who did not.The model scored 0.810 on a measure of distinguishing people who developed atrial fibrillation within 10 years from those who did not. Among 76,967 patients receiving ongoing primary or cardiology care at Massachusetts General…
Compared with another diabetes drug class, glucagon-like peptide-1 receptor agonists were linked to a lower rate of death over time (hazard ratio 0.56).Compared with another diabetes drug class, glucagon-like peptide-1 receptor agonists were linked to a lower rate of death over time (hazard ratio 0.56).
For 10-year heart failure prediction, a scan-based model scored 0.84 versus 0.72 for a clinical score in distinguishing future cases from people who remained unaffected.For 10-year heart failure prediction, a scan-based model scored 0.84 versus 0.72 for a clinical score in distinguishing future cases from people who remained unaffected.
In Massachusetts General Hospital’s test group, 10-year prediction scores were 0.87 for heart failure with reduced ejection fraction and 0.79 for preserved ejection…In Massachusetts General Hospital’s test group, 10-year prediction scores were 0.87 for heart failure with reduced ejection fraction and 0.79 for preserved ejection fraction.
Each 0.11-unit rise in an activity-rest rhythm measure was linked to a 25% lower relative risk of atrial fibrillation, an irregular heartbeat.Each 0.11-unit rise in an activity-rest rhythm measure was linked to a 25% lower relative risk of atrial fibrillation, an irregular heartbeat.
About 90% of the estimated cardiovascular disease burden linked to adolescent blood pressure involved levels not classified as high blood pressure today.About 90% of the estimated cardiovascular disease burden linked to adolescent blood pressure involved levels not classified as high blood pressure today.
An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher…An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher cardiovascular event risk.
Scan features scored 0.83 versus 0.74 for a clinical risk score in distinguishing who developed the condition; 1 would mean perfect separation.Scan features scored 0.83 versus 0.74 for a clinical risk score in distinguishing who developed the condition; 1 would mean perfect separation.
People flagged only by AI had cardiovascular-event hazard ratios of 1.21–1.69 versus those normal on both measures; ratios above one indicate higher risk.People flagged only by AI had cardiovascular-event hazard ratios of 1.21–1.69 versus those normal on both measures; ratios above one indicate higher risk.
A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.A 19-protein score achieved 0.80 versus 0.76 for clinical risk factors alone on a measure of how well it distinguished future heart failure cases.
Positive combined screens were linked to 3.4-fold and 4.3-fold relative heart failure risks versus negative screens at Massachusetts General and Emory, respectively.Positive combined screens were linked to 3.4-fold and 4.3-fold relative heart failure risks versus negative screens at Massachusetts General and Emory, respectively.
An artificial intelligence model outperformed combined clinical information and standard scan measurements in 5,732 older adults followed for a median 10.6 years.An artificial intelligence model outperformed combined clinical information and standard scan measurements in 5,732 older adults followed for a median 10.6 years.
Stroke prevalence was 4.6% among adults with poor sleep quality versus 2.6% among those with excellent sleep quality.Stroke prevalence was 4.6% among adults with poor sleep quality versus 2.6% among those with excellent sleep quality. Among 88,916 US adults surveyed in 2020, 2022 and 2024, a cross-sectional observational study linked poorer…
Under the new definition, people with obesity and clinical risk factors had higher cardiovascular risk than those without obesity, with an adjusted hazard ratio of 1.67.Under the new definition, people with obesity and clinical risk factors had higher cardiovascular risk than those without obesity, with an adjusted hazard ratio of 1.67.
A standard-deviation rise in the score was linked to a 0.60-unit increase in artery calcium scores on a base-10 logarithmic scale.A standard-deviation rise in the score was linked to a 0.60-unit increase in artery calcium scores on a base-10 logarithmic scale. Among 6,468 participants from three cohorts, an observational study examined associations between…
Elevated versus normal levels were linked to an adjusted hazard ratio—a comparison of risk over time—of 1.87 for heart and blood vessel deaths.Elevated versus normal levels were linked to an adjusted hazard ratio—a comparison of risk over time—of 1.87 for heart and blood vessel deaths.
Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.