Aging measures’ links to heart failure outcomes varied
In 3,194 people with heart failure, links between protein-based aging measures and outcomes varied with diabetes, high blood pressure and symptom severity.
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Editor of record: Boris Djordjevic · AgingResearch.News
People with heart failure—3,194 participants averaging 59 years old—were studied in an observational analysis of four international cohorts. Researchers used 4,778 blood proteins to estimate 13 aging gaps: differences between protein-predicted age and the age expected for someone’s actual age.
Over a median two years, 1,465 deaths or heart failure admissions occurred. All aging gaps were linked to this combined outcome. The associations varied most consistently with diabetes, high blood pressure and symptom-related activity limitations. For the whole-body age gap, the hazard ratio—a measure of relative risk over time—was 1.27 without diabetes versus 1.19 with diabetes for each standard-deviation increase, a measure of how widely scores varied.
Why it matters
The authors suggested that protein-based aging measures may help identify biological vulnerability in people with heart failure who are not already considered high risk by conventional clinical features.
Caveats
People with and without diabetes may have differed in other health characteristics that influenced their outcomes. The findings covered people with established heart failure and were reported in a conference abstract.
The paper
Clinical Modifiers of Proteomic Organ Age Gap Associations in Heart Failure
Univ of Pennsylvania Perelman Sch of Medicine
AHA Scientific Sessions 2026 Abstract, Nov 2, 2026
Presented at AHA Scientific Sessions 2026, abstract 17297
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