Drug use linked to fewer cardiovascular events and deaths
Use was linked to a 59% lower combined risk of cardiovascular events or death in women and 52% in men, compared with nonusers over a median 7.5 years.
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Interventions- Studied:
- Study in people
- Why it’s aging research:
- It studies an intervention with evidence of extending healthy life.
Editor of record: Boris Djordjevic · AgingResearch.News
Adults with overweight or obesity, with or without diabetes, were studied in a retrospective observational cohort comparing users and nonusers of drugs called glucagon-like peptide-1 receptor agonists. The matched groups included 145,008 women and 88,010 men. In the overall cohort, women averaged 50 years of age and men 55. Average body mass index, a measure of weight relative to height, was about 36 in both groups.
Over a median 7.5 years, drug use was associated with a lower combined risk of death from any cause, heart attack, heart failure, stroke caused by blocked blood flow, or major limb complications in both sexes. Women had fewer cardiovascular risk factors and diseases than men.
Why it matters
Heart and blood-vessel disease affects health in later life. Comparing outcomes by sex addresses whether women and men have similar associations between this drug class and major health outcomes.
Caveats
Drug use was not randomly assigned, and differences in patients’ health or care may have influenced the associations despite matching. The findings concern adults with overweight or obesity and were reported in a conference abstract.
The paper
UPMC
AHA Scientific Sessions 2026 Abstract, Nov 2, 2026
Presented at AHA Scientific Sessions 2026, abstract 14178
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