Ventricular volume

1. Ventricular volume mediates free water in humans (p-values < 0.01).

   “VENT differentially mediated the effect of HTN according to distance ( p ‐values<0.01), having least mediation in central WM.”

   Humansdifferentially mediated by ventricular volume according to distancecerebral white mattern = 3,303

   A dual‐pathway hypothesis to explain free water white matter spatial distribution related to vascular risk factors

   AAIC 2025 abstract·7 Jan 2026

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1. Low WMH volume decreases ventricular volume in humans.

   “The low group had lower mean ventricular volumes than the remaining and high groups.”

   Humanscompared to remaining and high groups

   Evidence and Characteristics of Favorable Aging Group Within the Framingham Heart Study

   AAIC 2025 abstract·23 Dec 2025

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1. female sex is associated with ventricular volume in humans (β=4.89, 95% CI: 1.33, 8.44).

   “larger ventricular volume (β=4.89, 95% CI: 0. 1.33, 8.44)”

   Humansadjusting for age and education levelbrainn = 838

   The relationship between sex and brain volume in a diverse sample of older adults differs by age group

   AAIC 2025 abstract·25 Dec 2025

1. Blood pressure is associated with ventricular volume in humans.

   “Subjects with higher casual and waking SBP and waking diastolic BP had larger lateral ventricles.”

   Humansbrainn = 155

   Ambulatory blood pressure and brain atrophy in the healthy elderly

   Neurology·10 Sep 2002

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1. Systolic blood pressure is associated with ventricular volume in humans.

   “greater waking and sleep SBP variability were associated with larger lateral and third ventricles.”

   Humansbrainn = 155

   Ambulatory blood pressure and brain atrophy in the healthy elderly

   Neurology·10 Sep 2002

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