ALPS index
2 papers4 findings
- Humans2
Effects
1Spatial navigation deficits
mediatesin humans1
1 study
Spatial navigation deficits
mediatesin humans1
ALPS index mediates spatial navigation deficits in humans.
“Mediation analysis confirmed the ALPS index's role in linking CPV to spatial navigation deficits.”
Humanslinking CPV to spatial navigation deficits
AAIC 2025 abstract24 Dec 2025
Upstream
3Subjective cognitive decline
downin humans1
1 study
Subjective cognitive decline
downin humans1
Subjective cognitive decline decreases ALPS index in humans.
“The SCD group exhibited significant spatial navigation deficits and glymphatic dysfunction, characterized by lower ALPS indices and higher CPV compared to controls.”
Humanscompared to controls
AAIC 2025 abstract24 Dec 2025
Alzheimer's disease
no changein humans1
1 study
Alzheimer's disease
no changein humans1
Alzheimer's disease has no effect on ALPS index in humans (p = 0.80).
“The ANCOVA analysis adjusting for age revealed no significant group difference in the ALPS index ( p = 0.80, Table 1).”
Humansadjusting for agebrain
AAIC 2025 abstract24 Dec 2025
Age
downin humans1
1 study
Age
downin humans1
Age decreases ALPS index in humans (r=-0.40, p <0.01).
“A negative correlation between the ALPS index and age was observed in the combined sample (r=‐0.40, p <0.01)”
Humanscombined samplebrain
AAIC 2025 abstract24 Dec 2025
Latest
10 in 12 monthsResearch Square
Hearing impairment is associated with impaired glymphatic function in middle- and older-aged adults: evidence from DTI-ALPS imaging
Preprint: cross-sectional study of 131 peopleBiomarkers
Human Brain Mapping
DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study
Cohort study of 204 peopleBiomarkers
Research Square
Working memory deficits under high cognitive load in older adults with insomnia disorder: associations with frontoparietal control network connectivity and glymphatic function
Preprint: case-control study of 80 peopleMechanisms
AAIC 2025 Abstract
Olfactory dysfunction relates to lower glymphatic functioning as measured by DTI‐ALPS in cognitively unimpaired individuals with family history of dementia
Cohort study of 1,369 peopleBiomarkers
AAIC 2025 Abstract
Evaluation of the ALPS Index as a Glymphatic System Biomarker Across the Alzheimer's Disease Continuum
Cross-sectional study in peopleAlzheimer's disease
AAIC 2025 Abstract
Glymphatic perivascular clearance and extracellular vesicles: neuroimaging & blood‐based biomarkers in mild cognitive impairment
Cohort study in peopleMild cognitive impairment
AAIC 2025 Abstract
Evaluation of the ALPS Index as a Glymphatic System Biomarker Across the Alzheimer’s Disease Continuum
Study in peopleBiomarkers