Unesterified cholesterol
2 papers1 finding
- Animals2
Interventions
1Primidone
downin C. griseus cells1
1 study
Primidone
downin C. griseus cells1
Primidone decreases unesterified cholesterol in C. griseus cells.
“treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells.”
Cellsin NPC1-null/mutant cells
European journal of pharmacology24 Jan 2021
Latest
1 in 12 monthsEuropean Journal of Pharmacology
Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice
Experiments in miceInterventions
Experimental Neurology
Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2
Experiments in miceInterventions
The Journal of Neuroscience
Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse
Experiments in miceInterventions
The American Journal of Pathology
Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy
Cross-sectional study in peopleEye