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Primidone

Intervention

1 paper3 findings

PubChemChEBIMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Animals1

Outcomes

3

Ataxia onset

no changein mice1

1 study

  1. Primidone has no effect on ataxia onset in mice.

    “although the first days showing ataxia, a typical symptom of neuromotor dysfunction, were not affected.”

    Animalsin NPC1-null miceoral application100 mg/kg/day

    Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice

    European journal of pharmacology24 Jan 2021

Lifespan

upin mice1

1 study

  1. Primidone extends lifespan in mice (approximately 5 days).

    “oral application of primidone (100 mg/kg/day) extended lifespan by approximately 5 days”

    Animalsin NPC1-null miceoral application100 mg/kg/day

    Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice

    European journal of pharmacology24 Jan 2021

Unesterified cholesterol

downin C. griseus cells1

1 study

  1. Primidone decreases unesterified cholesterol in C. griseus cells.

    “treatment with primidone reduced free-C levels in LE/LY in NPC1-null/mutant cells.”

    Cellsin NPC1-null/mutant cells

    Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice

    European journal of pharmacology24 Jan 2021

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