NPC1

18 papers1 finding

HGNC NCBI Gene Taxon

1 lab in 1 country

Animals17
Model organisms1

Effects

1

Motor function

downin mice1

1 study

NPC1 impairs motor function in mice.
“NPC1 loss triggered DNA damage, neuroinflammation, microglial and astrocytic activation, Purkinje neuron degeneration, and motor dysfunction.”
AnimalsNPC1 loss
NPC1 deficiency engages a lysosome-genome-immune program linked to neurodegeneration and cellular aging signatures
bioRxiv : the preprint server for biology13 Jul 2026Preprint

Latest

4 in 12 months

bioRxiv29 Jul

NPC1 deficiency engages a lysosome-genome-immune program linked to neurodegeneration and cellular aging signatures

Preprint: experiments in miceNeurodegenerative disease

bioRxiv25 Jun

Sexually dimorphic behavioural signatures of tau toxicity in adult Drosophila

Preprint: experiments in fliesMechanisms

GeroScience11 Apr

Molecular and histological characterizations reveal two distinct senescent microglia populations in Niemann-Pick disease type C mouse model

Experiments in miceCellular senescence

Cells26 Nov

cGAS/STING Pathway Mediates Accelerated Intestinal Cell Senescence and SASP After GCR Exposure in Mice

Experiments in micecGAS–STING signalling

Research29 Mar

Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulating α1,2-Fucosylation of Asah2 and Npc1

Experiments in miceStem cell maintenance

PNAS4 May

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

Experiments in miceMechanisms

International Journal of Molecular Sciences26 Mar

Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease

Experiments in miceInterventions

European Journal of Pharmacology24 Jan

Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice

Experiments in miceInterventions

EMBO Reports18 Sep

NPC1 enables cholesterol mobilization during long-term potentiation that can be restored in Niemann-Pick disease type C by CYP46A1 activation

Experiments in miceInterventions

Human Molecular Genetics1 Sep

AAV9 intracerebroventricular gene therapy improves lifespan, locomotor function and pathology in a mouse model of Niemann-Pick type C1 disease

Experiments in miceInterventions