Transdiagnostic polygenic risk scores

1. Transdiagnostic polygenic risk scores are associated with asymmetry-based brain-aging modes in humans.

   “Genetic coupling was mode-specific, with different modes aligning with distinct constellations of transdiagnostic PRS.”

   HumansAcross 12 neuropsychiatric/neurodegenerative disordersbrain

   Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways

   medRxiv·29 Dec 2025Preprint

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