Asymmetry-based brain-aging modes

1. Transdiagnostic polygenic risk scores are associated with asymmetry-based brain-aging modes in humans.

   “Genetic coupling was mode-specific, with different modes aligning with distinct constellations of transdiagnostic PRS.”

   HumansAcross 12 neuropsychiatric/neurodegenerative disordersbrain

   Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways

   medRxiv·29 Dec 2025Preprint

More on Transdiagnostic polygenic risk scores

1. Sex is associated with asymmetry-based brain-aging modes in humans.

   “Modes differed systematically by sex”

   Humansbrain

   Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways

   medRxiv·29 Dec 2025Preprint

1. Asymmetry-based brain-aging modes are associated with age in humans (Five age-linked modes replicated directionally).

   “We identified five age-linked asymmetry modes that replicated directionally in Cam-CAN.”

   HumansUK Biobank discovery with independent Cam-CAN replicationbrain

   Hemispheric Asymmetry Defines Brain Aging: Five Reproducible NMF Modes Linked to Sex, Lifestyle, Transdiagnostic Genetic Risk, and Molecular Pathways

   medRxiv·29 Dec 2025Preprint