1 paper
In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.In sorted cell populations, a machine-learning model found age-associated shifts in DNA marks towards a developmental family that includes connective-tissue cells.
Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.Mice lacking the enzyme MMP14 in bone-forming cells initially gained bone mass when young, but later developed severe bone loss driven by immune cells.
Simple DNA deletion counts showed an overall roughly 10-fold increase across ages 0.8 months to 90 years in people without radiation or chemotherapy treatment.Simple DNA deletion counts showed an overall roughly 10-fold increase across ages 0.8 months to 90 years in people without radiation or chemotherapy treatment.
Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a…Whole-genome sequencing of eight coral colonies showed somatic mutations followed power-law distributions, faced purifying selection, and helped age a colony to nearly a century.
Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.Diminished SATB1 in murine naive CD4⁺ T cells weakens TAD boundaries, rewires enhancer-promoter interactions, and increases proinflammatory gene expression during aging.
Aged Cladonema medusae show stem cell depletion, increased DNA damage, delayed wound closure, and defective blastema formation during tentacle repair.Aged Cladonema medusae show stem cell depletion, increased DNA damage, delayed wound closure, and defective blastema formation during tentacle repair.
Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.Researchers found that senescent epithelial cells secrete TGF-beta1 to reprogram fibroblasts into a matrix-remodeling state, which senolytic treatment can blunt.