Immunosenescent immune-cell signatures

1. Ascorbic acid decreases immunosenescent immune-cell signatures in mice.

   “Single-cell RNA sequencing of PBMCs revealed AA reversed immunosenescent signatures-increasing T/B cell populations and decreasing neutrophils/macrophages-mimicking youthful immune profiles.”

   Animalsaged C57BL/6 miceperipheral blood mononuclear cells0.1 mg/g every 2 days30 days

   Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation

   Immunity & ageing : I & A·5 Nov 2025

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