AHA Scientific Sessions 2026 Abstract
Aging shifts artery cell gene activity in high-cholesterol mice
An experiment comparing young and older mice found an immune-cell-like profile in artery muscle cells only when aging and high cholesterol occurred together.An experiment comparing young and older mice found an immune-cell-like profile in artery muscle cells only when aging and high cholesterol occurred together.
Mouse studyMechanisms
Who was studiedYoung and aged mice, against young high-cholesterol and aged normal-cholesterol mice
What changedMacrophage-like artery muscle cell profiles appeared only in aged high-cholesterol mice, not young high-cholesterol or aged normal-cholesterol mice
The catchDiet and genetic background differed between groups, complicating attribution to aging and cholesterol