1 paper
Veterans AffairsNational Institute on AgingUS$218.5k
Activation of SIRT3 as a Therapeutic Strategy for Alzheimer's Disease
Veterans AffairsVA Eastern Colorado Health Care System2019–2030
Investigating the role of SIRT3 in metabolic flexibility and proteostasis in the aging heart
National Institute on AgingOklahoma Medical Research FoundationUS$218.5k2022–2025
In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the…In mice with bone loss or fractures, honokiol promoted bone formation predominantly linked to sirtuin 3, while broader effects appeared only partly dependent on the enzyme.
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.The mycosterol restores mitochondrial metabolism by activating the LXRbeta-SIRT3-PGC-1alpha pathway to counter age-related muscle decline.