Chronic insomnia disorder

1 paper2 findings

Humans1

Effects

2

SIRT3

upin humans1

1 study

Chronic insomnia disorder increases SIRT3 in humans (Z=-6.223, P<0.001).
“The patients also had increased serum levels of sirtuins-1 (Z=6.718, P<0.001) and sirtuins-3 (Z=-6.223, P<0.001).”
Humansin comparison to healthy controls
Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder
Nature and science of sleep1 Mar 2026

SIRT1

upin humans1

1 study

Chronic insomnia disorder increases SIRT1 in humans (Z=6.718, P<0.001).
“The patients also had increased serum levels of sirtuins-1 (Z=6.718, P<0.001) and sirtuins-3 (Z=-6.223, P<0.001).”
Humansin comparison to healthy controls
Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder
Nature and science of sleep1 Mar 2026

Trial sponsors

University of Pennsylvania
1 trialPhase 41,200 people
The Third Xiangya Hospital of Central South University
1 trial172 people

Latest

1 in 12 months

Nature and Science of Sleep1 Mar

Changed Serum Levels of Sirtuin1 and Sirtuin3 and Their Correlations with Sleep Quality and Cognitive Function in Patients with Chronic Insomnia Disorder

Case-control study in peopleBiomarkers