SIRT1 protein expression

1. N1-METHYLNICOTINAMIDE increases SIRT1 protein expression.

   “Second, 1-MNA directly stabilizes and upregulates SIRT1 protein expression, enhancing sirtuin activity beyond what would be predicted from NAD+ elevation alone.”

   Review

   An Obscure Natural NAD⁺-Boosting Sirtuin Activator: N¹-Methylnicotinamide (1-MNA)

   ChemRxiv·16 Jul 2025Preprint

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1. Nanosecond pulsed electric field increases SIRT1 protein expression in rodents.

   “In vivo nsPEF treatments upregulated the expression of HIF-1α and SIRT1 in ECs and promoted neoangiogenesis in aged/senescent rodents' skin.”

   Animalsaged/senescent rodentsskin endothelial cells

   Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

   Regenerative therapy·18 Jun 2025

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1. Metformin increases SIRT1 protein expression in humans.

   “Compared to placebo, metformin increased SIRT1 protein expression and reduced p70S6K phosphorylation (a proxy of mTOR activity).”

   Human trialprediabetes; comparison with placeboperipheral blood mononuclear cells1500 mg/day2 monthsn = 38

   Metformin improves putative longevity effectors in peripheral mononuclear cells from subjects with prediabetes. A randomized controlled trial

   Nutrition, metabolism, and cardiovascular diseases : NMCD·24 Mar 2015

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