N1-METHYLNICOTINAMIDE

1. N1-METHYLNICOTINAMIDE extends lifespan.

   “Animal studies corroborate enhanced potency, showing significant lifespan extension and healthspan improvements with modest supplementation levels.”

   ReviewAnimal studies; species not stated

   An Obscure Natural NAD⁺-Boosting Sirtuin Activator: N¹-Methylnicotinamide (1-MNA)

   ChemRxiv·16 Jul 2025Preprint

1. N1-METHYLNICOTINAMIDE increases SIRT1 protein expression.

   “Second, 1-MNA directly stabilizes and upregulates SIRT1 protein expression, enhancing sirtuin activity beyond what would be predicted from NAD+ elevation alone.”

   Review

   An Obscure Natural NAD⁺-Boosting Sirtuin Activator: N¹-Methylnicotinamide (1-MNA)

   ChemRxiv·16 Jul 2025Preprint

More on SIRT1 protein expression

1. N1-METHYLNICOTINAMIDE inhibits NNMT.

   “First, 1-MNA functions as a feedback inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme responsible for nicotinamide methylation.”

   Review

   An Obscure Natural NAD⁺-Boosting Sirtuin Activator: N¹-Methylnicotinamide (1-MNA)

   ChemRxiv·16 Jul 2025Preprint

More on NNMT