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Nanosecond pulsed electric field

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 2 more
  • Animals1

Outcomes

6

Angiogenesis

upin rodents1

1 study

  1. Nanosecond pulsed electric field increases angiogenesis in rodents.

    “In vivo nsPEF treatments upregulated the expression of HIF-1α and SIRT1 in ECs and promoted neoangiogenesis in aged/senescent rodents' skin.”

    Animalsaged/senescent rodentsskin

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on Angiogenesis

SIRT1 protein expression

upin rodents1

1 study

  1. Nanosecond pulsed electric field increases SIRT1 protein expression in rodents.

    “In vivo nsPEF treatments upregulated the expression of HIF-1α and SIRT1 in ECs and promoted neoangiogenesis in aged/senescent rodents' skin.”

    Animalsaged/senescent rodentsskin endothelial cells

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on SIRT1 protein expression

HIF-1α protein expression

upin rodents1

1 study

  1. Nanosecond pulsed electric field increases HIF-1α protein expression in rodents.

    “In vivo nsPEF treatments upregulated the expression of HIF-1α and SIRT1 in ECs and promoted neoangiogenesis in aged/senescent rodents' skin.”

    Animalsaged/senescent rodentsskin endothelial cells

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on HIF-1α protein expression

ROS production

downin human cells1

1 study

  1. Nanosecond pulsed electric field decreases ROS production in human cells.

    “These effects were confirmed by concurrent reductions in SA-β-Gal activity and in ROS production, and increases in EdU-positive (DNA-synthesizing) cells.”

    Cellsd-galactose-induced senescencehuman umbilical vein endothelial cells

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on ROS production

Mitochondrial membrane potential

upin human cells1

1 study

  1. Nanosecond pulsed electric field improves mitochondrial membrane potential in human cells.

    “In vitro results showed that nsPEF treatment suppressed d-galactose-induced senescing effects as they rescued mitochondrial membrane potential, and activated HIF-1α and SIRT1.”

    Cellsd-galactose-induced senescencehuman umbilical vein endothelial cells

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on Mitochondrial membrane potential

Cellular senescence

downin human cells1

1 study

  1. Nanosecond pulsed electric field decreases cellular senescence in human cells.

    “Our data showed that nsPEF treatments rescued endothelial cells from d-galactose senescence.”

    Cellsd-galactose-induced senescencehuman umbilical vein endothelial cells

    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication

    Regenerative therapy18 Jun 2025

More on Cellular senescence

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