Short telomeres

Biomarker

3 papers4 findings

  • Human trial1
  • Humans2

Associations

4

Common carotid intima-media thickness

upin humans1OR 2.373

1 study
  1. Common carotid intima-media thickness raises the risk of short telomeres in humans (OR 2.373, 95%CI 1.4962-3.764).

    “the highest IMT-CC group showed a twofold greater risk of short telomeres compared to the reference group (<0.7mm; OR 2.373, 95%CI 1.4962-3.764)”

    Humansin coronary heart disease patients, compared to IMT-CC <0.7mmn = 903

    Telomere length is associated with arterial damage in the CORDIOPREV study

    Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis2 Dec 2025

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Ultra-processed foods

upin humans1OR 1.82

1 study
  1. Ultra-processed foods raise the risk of short telomeres in humans (adjusted OR: 1.82; 95% CI: 1.05, 3.22).

    “Those participants with the highest UPF consumption had almost twice the odds of having short telomeres compared with those with the lowest consumption (adjusted OR: 1.82; 95% CI: 1.05, 3.22”

    Humanshighest vs. lowest UPF consumption quartilesalivan = 886

    Ultra-processed food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project

    The American journal of clinical nutrition1 Jun 2020

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Dietary inflammatory index

upin humans1OR 1.8

1 study
  1. Dietary inflammatory index is associated with short telomeres in humans (OR 1.80, 95% CI: 1.03, 3.17).

    “multivariable-adjusted OR for short telomeres (z score ≤20th percentile) was 1.80 (95% CI: 1.03, 3.17) in a comparison between the highest (proinflammatory) and the lowest (anti-inflammatory) DII tertiles.”

    Human trialhigh cardiovascular disease riskleukocytesbaselinen = 520

    Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: cross-sectional and longitudinal analyses over 5 y

    The American journal of clinical nutrition9 Sep 2015

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Myocardial infarction

upin humans1

1 study
  1. Short telomeres raise the risk of myocardial infarction in humans (2.8- to 3.2-fold).

    “the risk of myocardial infarction was increased between 2.8- and 3.2-fold (P<0.0001) in subjects with shorter than average telomeres.”

    Humansleukocytes

    White cell telomere length and risk of premature myocardial infarction

    Arteriosclerosis, thrombosis, and vascular biology20 Mar 2003

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Funding

2 grants since 2025

National Institute on AgingUS$4.2mNational Institute of Diabetes and Digestive and Kidney DiseasesUS$150k

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