What does the research say about SA-β-gal positivity?

SA-β-gal positivity

There are 5 papers on SA-β-gal positivity in aging research: none in people yet, 1 in animals, 4 in cells. The newest story, Nov 13, 2026: “Fatty acid altered DNA marks in human fat-derived stem cells”.

Biomarker

5 papers study it112 more mention it4 findings

6 new papers in 30 daysSee all 117 papers on SA-β-gal positivity

Animals1
Cells4

Interventions

Sodium palmitate

upin human cells1

1 study

Sodium palmitate increases SA-β-gal positivity in human cells (Concentration-dependent increase).
“both raised mitophagy-associated and lysosomal puncta without preventing a concentration-dependent rise in senescence-associated β-galactosidase positivity”
Cellshuman adipose-derived mesenchymal stem cell250 and 500 μM24 h
Fatty acid altered DNA marks in human fat-derived stem cells
International journal of molecular sciencesNov 13, 2026

Upstream

ANGPTL4

upin human cells1

1 study

ANGPTL4 increases SA-β-gal positivity in human cells (shown by depletion and overexpression).
“ANGPTL4 depletion reduced LUAD-cell migration and SA-β-gal positivity, while its overexpression had the opposite effects and resulted in larger xenograft tumors.”
Cellsshown by depletion and overexpressionlung adenocarcinoma cell
Senescence-Related Transcriptomic Analysis and Functional Characterization of ANGPTL4 in Lung Adenocarcinoma
CancersNov 6, 2026

Associations

WNT4

upin pigs1

1 study

WNT4 is associated with SA-β-gal positivity in a swine renal ischemia/reperfusion injury model.
“we found the increased expression of Wnt4 and βcatenin correlating with SA-β Gal, p21, p16 and IL-6 positivity.”
Animalsin a swine renal ischemia/reperfusion injury modelkidney
Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury
AgingJul 8, 2019

Latest

30 papers in 12 months

International Journal of Molecular SciencesNov 13

Fatty acid altered DNA marks in human fat-derived stem cells

A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid.A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid.

Human cell studyMechanisms

Paper

Free Radical Biology & MedicineNov 7

Sorcin protein helped scar-forming liver cells keep dividing

Experiments in liver stellate cells traced the effect to RNA-containing clusters that reduced production of p53, a protein that helps regulate cell division.Experiments in liver stellate cells traced the effect to RNA-containing clusters that reduced production of p53, a protein that helps regulate cell division.

Cell studyMechanisms

Paper

CancersNov 6

Senescence-Related Transcriptomic Analysis and Functional Characterization of ANGPTL4 in Lung Adenocarcinoma

Experiments in human cellsCellular senescence

Paper

Journal of Functional FoodsSep 3

Hydrolyzed chicken meat extract and its bioactive cyclopeptides attenuate cellular senescence in HT-22 neurons via promoting autophagy through the SIRT1/AMPK/mTOR pathway

Experiments in cellsInterventions

Paper

International ImmunopharmacologyNov 13

Formononetin attenuates senescence-associated changes in models of gastric precancerous lesions: CALML4 as a candidate molecule

Experiments in human cellsInterventions

Paper

Inflammation and RegenerationNov 2

Generation of a senescent synovial organoid model using rat synovial fibroblasts treated with oxidative stress

Experiments in rat cellsCellular senescence

Paper

Ecotoxicology and Environmental SafetyOct 28

Bisphenol A caused aging-like injury in lab-grown human bladder cells

Experiments in primary human bladder-lining cells found that silencing the gene for ACSL4, a protein, or adding vitamin C lessened the chemical’s effects.Experiments in primary human bladder-lining cells found that silencing the gene for ACSL4, a protein, or adding vitamin C lessened the chemical’s effects.

Human cell studyMechanisms

Paper

Frontiers in PharmacologyOct 2

Melissic acid reduces senescence in human stem cells via cAMP signaling

A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.A screen of 800 natural compounds identified a phytochemical that activates autophagy and restores cell-cycle activity in models of cellular exhaustion.

Experiments in human cellsInterventions

Paper

Research SquareSep 30

Green Extraction of Flavonoids from Cedrus deodara Pollen with Deep Eutectic Solvents and Their Potential Anti-Senescence Properties

Preprint: experiments in miceInterventions

Paper

Research SquareSep 16

PRDX4 Alleviates Ovarian Aging by Suppressing Endoplasmic Reticulum Stress‑Related Ferroptosis in Granulosa Cells

Preprint: experiments in human cellsER unfolded protein response

Paper

See all 117 papers on SA-β-gal positivity