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Sodium palmitate

Intervention

3 papers mention it6 findings

PubChemChEBI

1 new paper in 30 daysSee all 3 papers on sodium palmitate

At a glance

The findings reach cells, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells: a single group. Worms or flies, mice and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Ministry of Education, Culture, and Science

What did studies of sodium palmitate find?

6

Studies of sodium palmitate measured 6 outcomes, among them nuclear CpG methylation, mitochondrial DNA copy number and SA-β-gal positivity.

Nuclear CpG methylation

downin human cells1

1 study

  1. Sodium palmitate decreases nuclear CpG methylation in human cells (29.87% to 26.84%).

    “Nuclear CpG methylation fell from 29.87% to 26.84%, uniformly across the genome”

    Cellshuman adipose-derived mesenchymal stem cell24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

More on Nuclear CpG methylation

Mitochondrial DNA copy number

downin human cells1−56% untreated

1 study

  1. Sodium palmitate decreases mitochondrial DNA copy number in human cells (56% of untreated).

    “Mitochondrial DNA copy number fell to 56% of untreated”

    Cellshuman adipose-derived mesenchymal stem cell24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

More on Mitochondrial DNA copy number

SA-β-gal positivity

upin human cells1

1 study

  1. Sodium palmitate increases SA-β-gal positivity in human cells (Concentration-dependent increase).

    “both raised mitophagy-associated and lysosomal puncta without preventing a concentration-dependent rise in senescence-associated β-galactosidase positivity”

    Cellshuman adipose-derived mesenchymal stem cell250 and 500 μM24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

More on SA-β-gal positivity

Mitophagy-associated puncta

upin human cells1

1 study

  1. Sodium palmitate increases mitophagy-associated puncta in human cells.

    “both raised mitophagy-associated and lysosomal puncta”

    Cellshuman adipose-derived mesenchymal stem cell250 and 500 μM24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

More on Mitophagy-associated puncta

Mitochondrial network fragmentation

upin human cells1

1 study

  1. Sodium palmitate increases mitochondrial network fragmentation in human cells.

    “the lower, obesity-range concentration fragmented the mitochondrial network over 24 h”

    Cellshuman adipose-derived mesenchymal stem cell250 μM24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

Mitochondrial membrane potential

upin human cells1

1 study

  1. Sodium palmitate increases mitochondrial membrane potential in human cells.

    “palmitate hyperpolarised mitochondria at both concentrations instead of depolarising them”

    Cellshuman adipose-derived mesenchymal stem cell250 and 500 μM24 h

    Fatty acid altered DNA marks in human fat-derived stem cells

    International journal of molecular sciences

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 1Sep 2026: 0Oct 2026: 0Nov 2026: 12 papers in 12 months
International Journal of Molecular Sciences

Fatty acid altered DNA marks in human fat-derived stem cells

A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid.A measure of chemical tagging on nuclear DNA fell from 29.87% in untreated cells to 26.84% after exposure to a saturated fatty acid.

Human cell studyMechanisms
Paper