2 papers1 finding
Metformin
upin rats1
Metformin increases respiratory capacity in rats (doubling).
“a washout of metformin resulted in an unexpected doubling of respiratory capacity in HCRs.”
Animalswashout in high-capacity runners (HCR)skeletal muscle
bioRxiv : the preprint server for biology4 Mar 2024Preprint
Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.Each doubling of spermidine intake was associated with 2.6 millilitres per kilogram per minute higher peak oxygen uptake in older people with coronary artery disease.
In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.In an experiment in mice with features of premature aging, a compound improved the performance of mitochondria, the energy-producing structures in muscle cells.
Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced…Aged mice on a high-fat diet and L-NAME showed impaired mitochondrial proteostasis rather than defective biogenesis, suggesting quality control may contribute to reduced cardiac reserve.