Molnupiravir

Molnupiravir shortens lifespan in worms.

“C. elegans exposed to higher concentrations of the drug (20-500 μM) exhibited significant lifespan reduction at all doses.”

Model organisms20-500 μM

Sub-Cytotoxic Mitochondrial Stress in Cardiomyocytes and Whole-Organism Toxicity in C. elegans Induced by Molnupiravir

International journal of toxicology·9 Apr 2026

Molnupiravir prevents respiratory sequelae in P. roborovskii.

“Treatment of acute disease with approved antivirals, paxlovid-like nirmatrelvir + ritonavir or molnupiravir, prevented long-term respiratory sequelae in aged animals.”

Animalsacute SARS-CoV-2 infectionlung

SARS-CoV-2 causes chronic lung inflammation and impaired respiratory capacity in aged Roborovski dwarf hamsters

Journal of virology·11 Aug 2025