Proteomic profile

Biomarker

3 papers1 finding

  • Humans2
  • Animals1

Associations

1

Aβ40

upin humans1

1 study
  1. Aβ40 is associated with proteomic profile in humans.

    “Between Alamar and Olink, Aβ40 had 456 significantly correlated proteins, NEFL had 379, and Aβ42 had 359 after Bonferroni adjustment ( p < .00001).”

    Humanscross-sectional proteomic comparison in ARIC cohort participantsplasman = 116

    Examination and Identification of distinct and shared proteomic profiles linked to Alzheimer's Disease biomarkers across multiple proteomic platforms

    AAIC 2025 abstract8 Jan 2026

More on Aβ40

Funding

1 grant since 2019

Canadian Institutes of Health Research (CIHR) Project GrantCA$5k

Latest

Nov 2025: 6Dec 2025: 18Jan 2026: 7Feb 2026: 8Mar 2026: 12Apr 2026: 12May 2026: 10Jun 2026: 16Jul 2026: 10Aug 2026: 22Sep 2026: 21Oct 2026: 9151 in 12 months
Depression and Anxiety

Sleep-linked blood proteins associated with depression risk

Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.Higher sleep-linked protein scores were associated with a lower depression rate during follow-up (hazard ratio 0.660); the abstract did not specify the comparison group.

Cohort study of 36,852 peopleDepression
Immunity

Immune cell ratio linked to healthy and disease-related aging

An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.An observational analysis of 2,609 apparently healthy people linked the balance of two memory immune-cell groups to healthy and disease-associated aging patterns.

Cohort study of 2,609 peopleImmune response
Journal of Affective Disorders

Higher fitness is linked to lower depression and anxiety risk

In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile.In a study of UK adults, the highest fitness quartile had a 24% lower depression risk and 17% lower anxiety risk than the lowest quartile.

Cohort study of 46,062 peopleAnxiety
bioRxiv

Bacterial molecule shapes behaviour and lifespan in worms

A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.A screen of 3,985 bacterial strains identified an iron-gathering molecule whose effects in worms depended on a stress response in cells’ energy-producing structures.

Preprint: experiments in wormsMechanisms
medRxiv

Transformer model predicts human disease across partial proteomes

Across 144 diseases, median AUC fell from 0.679 with 2,920 proteins to 0.637 when evaluated on 1,460 proteins without model refitting.Across 144 diseases, median AUC fell from 0.679 with 2,920 proteins to 0.637 when evaluated on 1,460 proteins without model refitting.

Preprint: cohort study of 53,014 peopleAI & data