Examination and Identification of distinct and shared proteomic profiles linked to Alzheimer's Disease biomarkers across multiple proteomic platforms

Abstract

Background: Plasma biomarkers like Aβ42/Aβ40, p ‐tau isoforms, and NfL are crucial for assessing Alzheimer's disease (AD) pathology. Advanced platforms such as SomaScan 11k, Olink 5k, and ALAMAR (NULISA‐based) enable precise protein measurement.