Plasma SAMe

Biomarker

1 paper1 finding

  • Human trial1

Interventions

1

S-adenosylmethionine

no changein humans1

1 study
  1. S-adenosylmethionine has no effect on plasma SAMe in humans.

    “SAMe supplementation did not alter plasma SAMe levels”

    Human trial1200 mg12 weeks

    S-adenosylmethionine as an epigenetic treatment of depression in adults with childhood trauma

    Epigenomics24 Apr 2026

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Neurology

Midlife Alzheimer’s marker linked to later memory decline

Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.

Cohort study of 1,515 adults with midlife and late-life blood samples, 11 yearsBiomarkers

Limit: The outcome was declining thinking skills, not dementia onset

Stroke

Blood protein linked to lower brain lesion volume

Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.

Cohort study of 5,260 UK Biobank participantsMechanisms

Limit: The postmortem comparison supporting lesion-related cathepsin B changes involved only eight samples