pTau217
Biomarker5 papers6 findings
- Humans5
Effects
1Aβ PET scans
downin silico1
1 study
Aβ PET scans
downin silico1
pTau217 decreases Aβ PET scans in silico (>60%).
In silicoin model screening paradigm
Tool converts plasma pTau217 values across testing platforms · medRxiv · 1 Oct 2026 · Preprint
Upstream
1Hypertension
downin humans1
1 study
Hypertension
downin humans1
Hypertension decreases pTau217 in humans (β = -0.52, p< .01).
Humansin patients with aECAD
Hypertension links to lower dementia risk in carotid disease · Research square · 10 Sep 2026 · Preprint
Associations
4Aβ positivity
upin humans1
1 study
Aβ positivity
upin humans1
pTau217 predicts Aβ positivity in humans (AUC=0.952).
Humans
Tool converts plasma pTau217 values across testing platforms · medRxiv · 1 Oct 2026 · Preprint
Alzheimer's disease
upin humans1
1 study
Alzheimer's disease
upin humans1
Alzheimer's disease is associated with pTau217 in humans (4.6 times higher).
“exploratory pooled pTau217 analysis showed it was 4.6 times higher in AD and negatively associated with most morphometric areas.”
Humansin AD
Global and Medial Temporal MRI Morphometry in Alzheimer's Disease and Cognitively Normal Adults: A Retrospective Association Study · Diagnostics (Basel, Switzerland) · 14 Sep 2026
Tau PET
upin humans1
1 study
Tau PET
upin humans1
pTau217 is associated with tau PET in humans (β = -0.092, 95% CI -0.158 to -0.027).
Humanslower periventricular diffusivity
MRI-derived periventricular diffusivity contextualizes plasma pTau217 associations with Alzheimer pathology: a discovery-validation study · Research square · 10 Sep 2026 · Preprint
Amyloid Centiloid
upin humans1
1 study
Amyloid Centiloid
upin humans1
pTau217 is associated with amyloid Centiloid in humans (interaction β = -0.096, 95% CI -0.154 to -0.037).
Humanslower periventricular diffusivity
MRI-derived periventricular diffusivity contextualizes plasma pTau217 associations with Alzheimer pathology: a discovery-validation study · Research square · 10 Sep 2026 · Preprint
Latest
5Tool converts plasma pTau217 values across testing platforms
Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.Assays predicted amyloid-beta positivity with AUCs of 0.929 to 0.952, while simulated pTau217 screening cut amyloid PET scans by over 60%.
Plasma pTau217 and recall test refine prognosis in Down syndrome
Using Alzheimer Biomarker Consortium-Down Syndrome data, researchers found combining plasma pTau217 with a cued recall task identifies cognitively…Using Alzheimer Biomarker Consortium-Down Syndrome data, researchers found combining plasma pTau217 with a cued recall task identifies cognitively stable adults facing clinical impairment within seven years.
Hypertension links to lower dementia risk in carotid disease
In adults with asymptomatic carotid disease, hypertension was linked to lower Alzheimer's disease risk (HR = 0.56) and higher cognitive scores (β =…In adults with asymptomatic carotid disease, hypertension was linked to lower Alzheimer's disease risk (HR = 0.56) and higher cognitive scores (β = 0.47).