Metabolic syndrome
upin humans1
Phospholipids are associated with metabolic syndrome in humans.
“There was a significant relationship between female sex, aging, elevated liver enzymes, elevated phospholipids, high homeostasis model assessment of insulin resistance, and MS defined by the IDF for Central Africa.”
HumansMS defined by the IDF for Central African = 126
International journal of general medicine8 Jun 2012
National Institute on AgingUS$2.8mNational Heart, Lung, and Blood InstituteUS$2.2mVeterans Affairs
Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis
National Institute on AgingUniversity of MinnesotaUS$648.2k2015–2027
Antibodies against Oxidized Phospholipids and Osteoporosis
Veterans AffairsCentral Arkansas Veterans Hlthcare Sys2019–2027
Lp(a) and Oxidized Phospholipids - Impact of Diets
National Heart, Lung, and Blood InstituteUniversity of California at DavisUS$571.3k2021–2026
Lipocalin 2 as a Regulator of Phospholipid Metabolism in Adipose Mitochondrial Bioenergetics
National Institute of Diabetes and Digestive and Kidney DiseasesUniversity of MinnesotaUS$193.8k2020–2026
Phospholipids in Aging and Disease
National Institute on AgingFederation of Amer Soc for Exper BiologyUS$49.4k2024–2025
National Heart, Lung, and Blood InstituteUniversity of California, San DiegoUS$177.6k2020–2025
Phospholipid and Sphingolipid Signaling in Drosophila
National Cancer InstituteDivision of Basic Sciences - NciUS$919.2k
In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent…In mouse midbrain and cultured human neurons, alpha-synuclein pathology led to shorter, more saturated lipid chains, an effect largely reversed in mice by intermittent fasting.
Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.Researchers identified PNPLA7 as an essential regulator of phosphatidylcholine catabolism necessary for maintaining mouse muscle fiber size and endurance.
In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).In 23,790 older adults, higher small HDL levels tracked lower dementia risk (hazard ratios 0.89 to 0.91), while very large HDL tracked higher risk (1.10 to 1.14).
Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.Restoring the fatty acid reversed visual decline in mice and cleared toxic oxidized lipids that otherwise trigger chronic microglial activation.
In elderly COVID-19 patients, altered phospholipid and bile acid metabolites tracked with T-cell senescence, inflammatory cytokines, and 180-day mortality.In elderly COVID-19 patients, altered phospholipid and bile acid metabolites tracked with T-cell senescence, inflammatory cytokines, and 180-day mortality.